Monday, July 06, 2020

Superspreaders

 

Recently in the New York Times there was article that suggested “Most People with Coronavirus Won’t Spread it. Why Do a Few Infect Many?"

Covid, it seems, is like a forest fire that can simmer and then sudden flash over.  While many diseases have a steady rate of infection (each person passes it on to two or three more), COVID seems different, It appears dependent not on the mass of victims to spread the disease,but on a few super spreaders.  10 percent of the positive seem to be infecting 80 percent of the subsequent positives. How is this possible?

In the right situations, the article explains, one person can become a “virus chimney”  All it takes is:

  1. The right day (likely a few days after infection)
  2. The right place (a crowded bar?  A church choir?  A meat packing plant?  A nursing home.
  3. An extended period of time where that superspreader is in contact with a group of people.

This is why we all need to wear masks and also to avoid contained spaces for extended periods of time.  We need to do this not only to help avoid corona ourselves, but to avoid being a virus chimney infecting others before we even know we have it.

Here is a great discussion of how masks work.  It contains a great line.  

My mask protects you.  Your mask protects me.

https://youtu.be/BA2BOT3A70w

Stay Safe.

Saturday, July 04, 2020

Forced Sedation

 

Interesting article on NBC news about the use of ketamine for sedating patients in police custody. 

Elijah McClain was injected with ketamine while handcuffed.  Some medical experts worry about its use during police calls.

The reporter centers the story around the tragic case of Elijah McClain, who was apparently walking down the street, wearing a face mask and listening to headphones when a 911 caller said he was acting strangely.  The police stopped him and ended up taking him down with a chokehold.  He said he couldn’t breathe and he vomited.  EMS came.  The officers told them he was on something and was exhibiting inhuman strength.  The medics gave Elijah a large dose of ketamine, and shortly after he was in cardiac arrest.  He was resuscitated, but suffered a brain injury and was unplugged.

In light of today’s awareness of cases of brutality, this case has aroused considerable attention and controversy.

The article seems to take the positions that 1) people should not be injected with a sedative during a police action and 2)  they should not be injected against their will.

The reporter talks to two college neuroscientists, a pharmacy professor and two lawyers including  someone from the American Civil Liberties Union.  He doesn't talk to an emergency physician or a paramedic.  An ED doctor or a paramedic would have likely provided insight into the real world conditions where these cases play out.

Here is my take on it.  First, I just want to say, this was a tragic case that should never have happened.  Just because someone is acting strangely or may be mentally ill (unless they are bothering someone or are observed committing a crime), they probably shouldn’t be physically restrained.  Where I work in Hartford there are a lot of people who act strangely, but once you know them, you learn they are not acting strangely for themselves.  There are just a lot of strange people out there, and not everyone should be held to the normal person standard. 

In this blog post, I only want to address why a paramedic would give someone ketamine or a sedative like Versed or ativan (benzodiazepines) against their will.  (Note: I do it quite frequently.)  We don’t carry ketamine in my section of Hartford, but as an EMS clinical coordinator that oversees several EMS services, we approve ketamine for use in certain circumstances, including to sedate violent patients. 

Our statewide paramedic protocols call for a number of measures to calm someone down and deescalate scenes.  It is not uncommon for us to respond to a violent EDP (emotionally disturbed person).  In many cases, the patient may be on drugs such as PCP and are resisting efforts. They may be naked in the middle of winter walking down the street.  (PCP makes people hot and it is quite common to have them disrobing in public). They may be smashing windows or merely threatening others.  I have had such people jump out of open windows.  They may also be schizophrenic, off their meds and talking about killing themselves or others.  If they are just plain crazy, standing on a street corner talking to themselves, as long as they know where they are, and have no intention of hurting themselves or others, we leave them alone.

Patients may only be restrained under the following indications:

Any patient who exhibits an altered mental status and may harm himself, herself, or others or interfere with their own care may be restrained to prevent injury to the patient or crew. Restraining must be performed in a humane manner and used only as a last resort.

We are authorized to do both physical and chemical restraint.  if someone fights against the physical restraints, I will chemically restrain them.

Continued patient struggling against restraints may lead to hyperkalemia, rhabdomyolysis, and/or cardiac arrest, chemical restraint may be necessary to prevent continued forceful struggling by the patient.

When I arrive on scene, I try to talk to the person, who the police may be holding down, sometimes in handcuffs, sometimes not.  If the person is alert and oriented and can carry on a normal conversation, I will ask the officers to let them up and take off their handcuffs.  If they are still resisting and are out of their minds, I will sedate them per out protocols.  The sedation works wonders.  It takes a few minutes to work, and I will urge everyone on scene to resist agitating them further, and let the medicine take hold.  I get them on the stretcher, we take the cuffs off and they are often sleeping like babies by the time we arrive at the hospital.

Paramedics do not medicate at the request of police.  Paramedics medicate based on their own medical guidelines to protect the patient and others from injury.  If a paramedic medicates a person, they are not transported to the jail, but to the hospital where they receive full emergency evaluation and care.

I try to put myself in the situation of responding to this particular case.  If I show up and if police are fighting with a man and they tell me he is on something and is showing extra human strength I am inclined to believe them (provided their description seems to match what is occurring in front of my eyes) and I would be inclined to sedate the patient if it appeared what the police were saying was true.  

As far as the excessive dose Elijah McClain received, I will say it is not always easy to properly estimate a patient’s weight or age in a chaotic setting.  We can’t have them step up on a scale as they might in a doctor’s office.  The fact that they estimated his weight at 220 pounds is curious because 220 pounds is 100 kilograms, which makes estimating the dose of ketamine much easier than if a patient weighed less.  At 5 mg per kg, the dose would be 500 mg.  Easy math to do in the head.  If the patient weighs 140 pounds, you would have to do the math  140 divided by 2.2 equals 63.6 kilograms.  Then 5 X 63.6 gives you a dose of 318 milligrams, about 2/3s of what he actually received.  A bit more complicated math, harder to do in your head than with the 220 pound/100 kilogram patient.

Maybe EMS should be more cautious of the story they receive when they arrive, but I can say based on experience, when the police say that the patient is violent and has superhuman strength, that is usually the case.  I have seen small women on PCP throw large officers off themselves.  I have seen police officers have the s kicked out of them, all the while employing only defensive tactics against people to avoid hurting them.  I have also seen officers respond back with what I might consider excessive counterattack.  The point is there are many mentally ill patients who are violent and there are a lot of drugged out patients who are also violent.  Sedating them is better than wrestling them or having someone, patient or medical worker, get hurt.  

As far as dosing, EMS needs to improve its weight estimating abilities, and should probably err on underestimating, particularly with a drug such as ketamine.

 

More Opioid Deaths?

 

Is the COVID epidemic causing increased opioid overdose deaths? No one knows for certain, but the head of the White House Office of Drug Policy is speculating that it has, citing increased death statistics from a few states such as Kentucky.

Pandemic unleashes a spike in overdose deaths

Here in Connecticut we won’t have an official answer until the Connecticut Medical Examiner’s Office releases its first six months of 2020 data (likely at the end of August).

I am involved with a statewide SWORD program that tracks EMS reported opioid overdoses.  Unfortunately, this program under reports fatal overdose deaths.  There are several reasons:

  1. EMS compliance with reporting is estimated to be only 70%.
  2. EMS often cannot ascribe the cause of a death to an overdose lacking eyewitness accounts of visible paraphernalia on scene.  (Example --A fifty year old lying dead in bed with rigor mortis and dependent lividity could have died from any number of causes from a heart attack to sniffing a bag of heroin that was either flushed down the toilet or removed from the scene by a friend prior to EMS arrival).
  3. Some EMS reported nonfatal overdoses turn into fatal overdoses after the patient is delivered to the emergency department.

Based on the last four months of 2019 and the first four months of 2020, the SWORD statistics show roughly the same number of fatal overdoses.  April had the highest number of fatal overdoses for the first six months of 2020, but deaths reverted to the mean in May and June. 

It is hard to know for certain if fatalities are increasing because of COVID when you lack year to year monthly comparisons as well as a full understanding of all the factors (strength of supply, for instance) that could be at play.

The worry with COVID-19 is that increased overdoses could be caused by loneliness, isolation, decreased access to services, and possibly changes in the drug supply causing users to find unfamiliar dealers.

From the anecdotal perspective of the paramedic on the street, I can’t say there are more or less deaths.  There are still too many.  I did three presumptions in the last month, one in a port-o-potty, on a mattress in a vacant apartment, and one in a halfway house where the victim still had the needle in his arm.  All there were long dead when I got there.

I worked the city yesterday in the fly car, and while there were no fatals when I was on, I still responded to six overdoses (seven patients) in ten hours.  Three were opioid-related (two heroin--both received bystander narcan!, one unknown opioid), one was PCP (two patients on PCP at same call), one was cocaine, and one was vodka.  Now, yesterday was a Friday of a holiday weekend, shortly after the first of the month so there were plenty of reasons to expect a busy day beyond people trying to escape the COVID blues.

My friends on Park Street say there is no shortage of supply, and that prices have actually dropped from $30-35 for a bundle of ten bags to $25.  Is that because it has been harder for people to get to Park Street to buy their drugs because of lockdowns?  Are people short on cash (and unable to afford drugs) because they’ve lost their jobs? Not that losing a job has been a hindrance to people finding drugs.  Are dealers are having to drop their prices to get rid of excess supply?  Or maybe more drugs are getting through?  

All I know is there has been no let up in the dispatches for overdoses.

COVID-19 has killed many Americans both directly and indirectly.

Hopefully, this crisis is bringing to light the holes in our health care system, and will move us closer to becoming a country with a health care system that leaves no one behind.

Happy July 4th!

Thursday, July 02, 2020

Golden Hour of Trauma

 R. Adams Cowley, the founder of Maryland's well-known Shock Trauma hospital in downtown Baltimore, famously said:

"There is a golden hour between life and death. If you are critically injured you have less than 60 minutes to survive. You might not die right then; it may be three days or two weeks later -- but something has happened in your body that is irreparable."

The Merriam-Webster On-Line dictionary defines "golden hour" as "the hour immediately following traumatic injury in which medical treatment to prevent irreversible internal damage and optimize the chance of survival is most effective."

The 2nd edition of the Prehospital Trauma Life Support said "The critical trauma patient has only 60 minutes to reach definitive surgical care or the odds of a successful recovery diminish dramatically."

(It is my guess that this is no longer in the current edition.)

The following quotes are from a 2001 Academic Emergency Medicine journal article:

"The Golden Hour: Scientific Fact or Medical Urban Legend?"

“The golden hour justifies much of our current trauma system...scoop and run, aeromedical transport, and trauma center designations with trauma teams in place are, in part, predicated on the idea that time is a critical factor in the management of injured patients....While it seems intuitive that less time is better for trauma patients, there are risks and costs involved in attempting to deliver patients to trauma centers within an hour...These may be justified if there is a benefit, but may not be if there is no proven benefit or if the benefit applies only to certain circumstances.”

In the article they researched Cowley and any mention of the golden hour. What they found was articles referencing articles that referenced articles that had no reference.

A text on trauma edited by Cowley contains a chapter authored by Shakar, which discusses “Cowley’s Golden Hour,” referencing a 1976 Cowley article.

“The 1976 article …describes Maryland’s trauma system and states that the first 60 minutes after an injury determines a patient’s resulting mortality.” It references a Cowley paper of 1975.

“1975 Cowley article states ‘the first hour after injury will largely determine a critically-injured person’s chances for survival,’ but no data or reference is provided.”

They they looked at the scientific evidence about time and trauma. They found research studies both supporting a link and not supporting a link. As a rule the articles had poor quality, selection bias, small samples, and uncontrolled variables.

These were their conclusions:

“Our search into the background of this term yielded little scientific evidence to support it.”

“There are no large, well-controlled studies in the civilian population that either strongly support or refute the idea that faster is universally better in trauma care.”

“The intuitive nature of the concept and the prestige of those who originally expressed it resulted in its widespread application and acceptance.”

Which leads me back to a story I heard many years ago about the origins of the golden hour. Cowley, trying to win support for a the shock trauma hospital and what would become Maryland's elite helicopter program that would fly trauma victims from all over the state to the Baltimore hospital, determined with a helicopter any trauma victim in the state could reach the hospital in 60 minutes, thus "the Golden Hour."

Whether that story is true or not, I don't know. I do know there is nothing magic about 60 minutes. True some few may only have sixty minutes, but some have only forty, some five, and some none at all, while others may have two hours, two days or a lifetime.

Prehospital people need to look at each patient individually, weigh the risks (lights and sirens versus with traffic, helicopter versus ground), use their best judgment and common sense on a case by case basis. Err on the side of the patient. When in doubt contact medical control.

Clearly the more critical a patient the less time they have. Some patients truly need scoop and run. Ten minutes scene time won't cut it for them, many others may benefit by a slower, safer pace.

Promoting a definite time, not supported by evidence, serves no one.

***

A version of this post first appeared on this blog in 2009.

Wednesday, July 01, 2020

Yet To Come

 

My daughter had her first softball game of the summer yesterday. It was the first time she wore a uniform since her basketball team's playoff run was stopped in March with the first Corona cancellations.  Last night they got mercied 17-5 but it was a beautiful night and she got two hits. They were supposed to play again tonight, but a thunderstorm came up and drenched the fields. Afterward there was a gorgeous rainbow, but with more rain on the way, they called the game.

We came home and had dinner. Earlier that afternoon, I stopped at Bear’s Smokehouse and picked up our local “farm share” along with two pounds of smoked burnt ends. Every Tuesday we pick up a bag of fresh picked farm products. Tonight they had a head of butter lettuce, peapods, zucchini, mint and fresh picked strawberries, juicy berries that actually taste like strawberries not the bland flavor the fat pretty-looking grocery store ones have.

After dinner I lay down and read some news stories about COVID on my computer. Connecticut dropped under 100 hospitalized cases and their positive test rate was its lowest ever at 0.7%.

Daily coronavirus updates: Connecticut hits largest number of COVID-19 tests in a single day, lowest rate of positivity to date

Outside the state, COVID-19 is growing crazy, particularly in places like Florida, Texas, Arizona and California, many setting record highs. Dr. Faucci says if we don’t get it under control we could see 100,000 new cases a day. The World Health Organization says the worst is yet to come. People are still fighting over wearing masks. The governors of many states have said they won’t lock down again even though their states are on fire.

Here in Connecticut, our governor just added more states to the list of states with restricted travel to Connecticut. Anyone coming into Connecticut from California, Georgia, Iowa, Idaho, Louisiana, Mississippi, Nevada, Tennessee, Alabama, Arkansas, Arizona, Florida, North Carolina, South Carolina, Texas, and Utah must quarantine for 14 days after their arrival here or obtain a negative COVID test within 72 hours.

We knocked COVID down here, but I’m back to the old feeling I had in our earliest days, looking up to the hilltops, which are now empty, waiting for the enemy to appear again against the sky, and bring death down upon us.

***

LA doctor on coronavirus surge: 'There's going to be a lot of death coming'

'The worst is yet to come,' WHO warns about the pandemic