Saturday, December 30, 2017

Angry Snowman-Naloxone Refusals

 

An older man with a cell phone meets us at the door to the apartment lobby. His hands shake. He motions for us to follow toward the stairs.

“What’s going on?” I ask.

“I just went out for ten minutes and I came back and found him.”

“Is he breathing?” I ask.

But he does not answer. I take the stairs two at a time, carrying my house bag over my shoulder and the monitor in my hand. I can barely keep up with him his steps are so quick. I follow him up to the second floor, and then down a long hallway to an apartment whose door opens into the living room. A large man in a sofa chair leans to the left motionless. I can only see him from behind. I come around the side and see he is blue and not breathing. I grab his arm, expecting to find rigor, but the arm is limber and the man emits an agonal gasp. He has a bounding carotid pulse. He has to be two sixty, muscle shirted with tattoos, I’m guessing late thirties. My partner gets out the ambu bag while I get my med kit from the house bag. I quickly screw the narcan vial into the injector and attach the atomizer. 2 milligrams up the nose, one in each nostril. A oral airway in the mouth. We strap on an ETCO2 cannula. 100. It doesn't get any higher.  He needs ventilation.  Fortunately, he bags easily. I go to put the 02 sat sensor on him, but I have to switch from the left hand to the right. His left hand is missing at the wrist. In no time his sat is 100%, but we are still breathing for him. His ETCO2 is still high in the 80s.

“He’s going to be okay,” I tell his father. “We’re breathing for him now, but he’ll come around. You called in time.”

He doesn’t look like he believes me.

Thirty seconds later, the patient’s end tidal drops to 39 and his chest begins to move. He is no longer blue.

“See, he is breathing on his own now,” I tell the father.

“Found them,” my partner says. He has found the heroin bags in the trash can. In his gloved hand he shows us the bags. They have a blue inked stamped picture of an evil, angry snowman. We’ve seen the brand before.

“Do you have narcan?” I ask the father now, while we wait for his son to come all the way around.

He shakes his head.

“You have to get it.”

“He’s been clean.”

“It doesn’t matter. People relapse. It’s expected. You have to always have Narcan around just in case. It can save his life if we don’t get here quick enough.”

The patient opens his eyes and looks around. “Hey, here we are,” I say. The patient pulls the ETCO2 cannula out of his nose.

“You oded.” I say. “We gave you Narcan. You weren’t breathing.”

“I did not,” he said. “I don’t do drugs.”

“Felix,” the father says to him sternly.

“Look, man,” I say. “Here’s the oral airway we had down in your throat. Here’s our ambu-bag we used to breathe for you. Here’s the Narcan injector. And there are your heroin bags. Snowman, sound familiar?”

“Get out of my house. Leave me alone!” he says. “I know my rights.”

“No, we really should take you to the hospital. What we gave you doesn’t last as long as the heroin, you could od again.”

“I told you. I didn’t use.” He stands now and because of his size he reminds me of a bear on his hind legs. Or maybe an angry snowman. He swats down our suggestions as he stands and points toward the door. “Get out. I know my rights, you can’t trample on my rights.”

I wish I had a picture of what he looked like all blue and slumped over in his chair when we got there to show him. It occurs to me I could have had his father take a picture of him that we could later show him. But then I think he knows he overdosed and he is both in withdrawal now, his high stolen, and angry with us for still being there.

I try to engage him about the potential dangers, warning him he could die. He will not listen to me or his father, who attempts to help.

The fire department responders ask if we want the police called.

I know if we call them, they will come and they will yell at the man who will yell at them. Chests will be puffed out. The message will be go to the hospital or you will be arrested. It is threat that works most of the time. But the truth is the man is within his rights to refuse. He knows where he is, knows the day of the week. When I ask him who is president, he thinks a moment, and then says, “That white prick.”: Everybody laughs. No matter your political views, you have to give him credit for the answer. A man’s entitled to his opinion.

I don’t ask for the cops. If we transport him, he will just leave the hospital AMA as soon as we get there. He is clearly not ready for rehab. And his father will be there to monitor him.

A prudent call to medical control for a high-risk refusal. The doctor reiterates the dangers but agrees if he is alert and oriented,you cannot force him to go.

I tell the patient, “We are going to leave, but you need to listen to me first.”

“No, you need to listen!  I know my rights.  Get the fuck out of my apartment!”

I keep my voice calm, and start going through my harm reduction spiel. I tell him if he is going to use heroin, he must never do it alone. He and his father need to make certain they have Narcan in the house. I tell them where to get it. Go to the needle exchange van or go to a local pharmacy. If you bring your Medicaid card, they will write you a prescription, train you and give it to you for little to no copay. I tell him about Fentanyl, how it clumps so one bag may be relatively mild, the next could contain a fatal dose. I tell him not to mix with benzos. I tell him if he has a period of abstinence, he should start back with a much smaller dose. I tell them if there is a overdose and they call 911, no one will be arrested unless they are dealing drugs.

He won’t look at me, but he is listening.

Finally, I write down the opioid hotline number, which I leave on the kitchen table, and tell the father and the son to not hesitate to call 911 at any time. The father thanks us for saving his son.  He shakes our hands.

“Now get the fuck out of my apartment!” the son says.

And we leave.

***

This is the first refusal I have taken after giving Narcan. I have done many refusals after waking patients up with stimulation. Data I have seen shows that close to 98% of the Naloxone administrations in our city ended up being transported. I don’t have the hospital data on the number of patients who left there AMA, but I suspect it is probably in the 10-15% range.

A 2017 Clinical Toxicology study Do heroin overdose patients require observation after receiving naloxone? concluded:

Patients revived with naloxone after heroin overdose may be safely released without transport to the hospital if they have normal mentation and vital signs. In the absence of co-intoxicants and further opioid use there is very low risk of death from rebound opioid toxicity.

https://www.ncbi.nlm.nih.gov/pubmed/21612385

A 2016 article in Prehospital Emergency Care, Assessing the Risk of Prehospital Administration of Naloxone with Subsequent Refusal of Care, concluded:

The practice of receiving pre-hospital naloxone by paramedics and subsequently refusing care is associated with an extremely low short- and intermediate-term mortality. Despite an evolving pattern of opioid abuse, the results of this study are consistent with previously reported studies.

A 2011 study, No deaths associated with patient refusal of transport after naloxone-reversed opioid overdose published in Prehospital Emergency Care, found that out of five-hundred fifty-two patients who received naloxone and then refused transport, none of them died (as recorded by the medical examiner's office) within the next forty-eight hours.

Despite these studies, you should always do your best to try to get the naloxone-reversed patient to go to the hospital. But in the end, if they are alert and oriented, all you can do is give them a harm reduction talk. Many EMS services even go so far as to leave a naloxone kit. Connecticut is working on a similar protocol.

Here are some other thoughtful discussions of the issue:

‘Treat and Release’ after Naloxone – What is the Risk of Death?

Pro Bono: Naloxone and the Refusal Conundrum

Officials: More OD victims refusing ambulance transport after naloxone revival

Tuesday, December 26, 2017

Chest Wall Rigidity

 

You are called for a seizure in the men’s room at McDonald’s. You arrive to find an approximately thirty-year old man stiff and purple, gurgling.

“Versed?” Your paramedic student says as you break out an ambu-bag.

“Check his pupils.”

“Pinpoint.”

You hand him Naloxone. “Give him 1.2 IM,” you say.

He looks at you like you are testing him.

“Go ahead. Right in the thigh.”

You normally give Naloxone IN, but when the patient is either in full respiratory arrest or in this seizure like state, you like to go IM because it works quicker.  You toss the ambu-bag to a firefighter who has just arrived. It takes him a moment to get the seal. His first breath is ineffective. You take out an oral airway and slip it in his mouth as the tension seems to go away and the man destiffens. His ETCO2 is 100, but gradually comes down to 70, then 60, then quickly drops to 35. In another moment, the man’s eyes are open, and he is looking around in panic.

“You ODed,” you say. “You are in a public restroom. We just gave you narcan.”

“What, I don’t do drugs,” the man says. “I’m fine.”

“Found it,” your partner says. He holds up a orange capped syringe and two torn glassine envelopes labeled Smurf he has removed from the trash can under the sink.

Afterwards, you discuss the call with the student. “How did you know it was an OD?” he asks.

“I’ve seen it several times now,” you say. “I use to think it was a hypoxic seizure, but now I’m not so certain. Have you ever heard of chest wall rigidity?”

He hasn’t. You elucidate.

Chest wall rigidity is a known, but rare side effect of IV fentanyl in the clinical setting. It is most likely caused by pushing large amounts too fast, but it has also been produced by small amounts. The mechanism is not fully understood. The skeletal muscle of the chest wall stiffens and the stiffness can extend into the abdomen, extremities and face. Patients suffering from the syndrome are difficult to ventilate. It has been speculated that the rigidity may extend into the glottis, causing airway obstruction. The syndrome responds to naloxone.

When you first had fentanyl added to your paramedic formulary there was discussion of rigid chest as a side effect, but despite over a decade of pushing fentanyl nearly every shift, and in aliquots of 100 mcgs, sometimes up to a max of 300 mcgs, you have never seen rigid chest syndrome or heard of it happening to another medic.

When you first heard the speculation that illicit drug users might be suffering from it, you poo-pooed it. Even though you have seen the stiffening, it seemed like, and may in fact be, a hypoxic seizure as the brain is deprived of oxygen, except it doesn’t look like the hypoxic seizures you have seen in patients who seized and then went into arrest. This seizure is totally tonic -- rigid muscles with no spasming -- and it persists.

Fentanyl Ads a New Terror for People Abusing Opioids

You research chest wall rigidity. Most of the literature on it is old, but there is a 2013 Clinical Toxicology article that posits the very question you are seeking to answer.

Could chest wall rigidity be a factor in rapid death from illicit fentanyl abuse?

The authors examined 48 fentanyl deaths, and found that an examination of metabolites suggested that at least half of the deaths had been very rapid consistent either with chest wall rigidity or perhaps simply a high enough dose to cause sudden respiratory arrest, followed quickly by death. They cite two prehospital run forms documenting difficulty ventilating until naloxone was given.  It is not a very convincing article -- it is mainly just speculation, but reading some of the sources the author cite was very informative. One was a 1993 study, Fentanyl-induced rigidity and unconsciousness in human volunteers. Incidence, duration, and plasma concentrations, in which 50% of the human volunteers who received fentanyl at a dose of 15 mcg/kg administered at 150 mcg/min. (15 100 mcg vials in 10 minutes for 220 lb). Were observed to develop chest wall rigidity. This is the equivalent of 15 100 mcgs vials of fentanyl -- way more than we would ever give one of our patients.

How much fentanyl are illicit users injecting? Considering a 0.1 gram bag of 50% pure heroin is the equivalent of 10 100 mcg vials of fentanyl, it does not seem unreasonable that illicit users, many of whom inject up to 10 bags at a time, are injecting enough fentanyl to cause chest wall rigidity. While there is very poor quality control from batch to batch even from bag to bag within a batch as fentanyl tends to clump and not mix easily, I have no doubt that some users are suffering from this side effect.

What does it mean for your practice?

Consider opioid overdose in tonically seizing patients who you suspect may be illicit drug users. It is likely a syringe will be in close proximity. (Could it be caused by inhalation as well? At the high doses they are using, it could be possible.) If you have a patient who’s chest seems stiff and you have trouble ventilating, consider naloxone. If the patient is suffering rigid chest syndrome, it should immediately get better.

A lingering question I have is if someone develops rigid chest wall and they arrest, how long after they become asystolic until the rigidity subsides. If the rigidity caused closure of the glottis, will the glottis open on asystole?  Every hypoxic seizure that led to cardiac arrest I have seen, the patient immediately became flaccid. I don’t know if this is the case with chest wall rigidity.  If you have someone you can’t ventilate, consider naloxone. If the chest is too rigid to do CPR (and the rigidity persists) the drug may not circulate and the person may die in spite of your efforts.

 

Sunday, December 17, 2017

Naloxone in Cardiac Arrest

  

Case # 1

You find the fifty year old man supine on the floor with the fire department doing CPR. Their AED announces, “No shock advised. Continue CPR.”

You set your monitor by the man’s head and connect the fire department’s pads to your monitor, while your paramedic student quickly places an IO in the man’s tibia. As you approach the two minute mark, you charge the monitor, and then order stop CPR. The patient is in asystole. “Continue CPR,” you say, as you harmlessly dump the charge by hitting the joule button.

Just then the man’s wife announces, “Oh, my God! He was using heroin.” She holds the empty bags she has just found in the trash can. “He used to use. He’s been clean for five years.”

What drug do you give?

***

Epinephrine.

According to the 2010 AHA Guidelines

There is no data to support the use of specific antidotes in the setting of cardiac arrest due to opioid overdose.

Resuscitation from cardiac arrest should follow standard BLS and ACLS algorithms

Naloxone has no role in the management of cardiac arrest.

Opioids bind to brain receptors that suppress respiration. The patient, if not treated in time, becomes hypoxic and may soon go into cardiac arrest. Giving the patient in asystolic arrest Naloxone will do nothing to restart the patient’s heart. The patient is in the same condition as someone who has suffered an airway obstruction. Hypoxia is the killer. The patient without a heart beat will not be able to breathe on their own without restoration of the heart beat. You are already taking care of the breathing part with your bag-valve mask.  The priority is getting the heart restarted. That is what epinephrine does.   This patient needs good CPR. Ventilation with a bag-valve mask and epinephrine to get his heart started.

***

Case # 2

You are a basic EMT. You find the fifty year old man supine on the floor with the fire department doing CPR. Their AED announces, “No shock advised. Continue CPR.”

Just then the man’s wife announces, “Oh, my God! He was using heroin.” She holds the empty bags she has just found in the trash can. “He used to use. He’s been clean for five years.”

You feel for a pulse, but find nothing. “Continue CPR,” you say.

What do you do next?

***

Naloxone.

Why? Because even though you can’t feel a pulse, the patient may have a hard one to palpate. He may, in fact, just be in respiratory arrest. You can give Naloxone while you provide CPR. If the patient is in a narrow complex rhythm, they may resume breathing on their own. If you are a medic in this situation and you find a pulseless man with a narrow complex rhythm, you should give Naloxone, while continuing to perform CPR.

The AHA Guidelines for BLS state:

Patients with no definite pulse may be in cardiac arrest or may have an undetected weak or slow pulse. These patients should be managed as cardiac arrest patients.

Standard resuscitative measures should take priority over Naloxone administration, with a focus on high-quality CPR (compressions plus ventilation). (Class I, LOE C-EO)

In October 2015, the guidelines were updated to add:

It may be reasonable to administer IM or IN Naloxone based on the possibility that the patient is not in cardiac arrest. (Class IIb, LOE C-EO).

I have had a couple calls this year where I could not feel a pulse in an apneic patient who I suspected of opioid overdose.

We initiated CPR. I had a narrow complex rhythm on the monitor. I gave Naloxone IM, and after several minutes, the patient regained a respiratory drive. We were able to feel pulses and so stopped CPR. In both cases, I suspect the patients simply had weak or hard to palpate pulses in the first place.

Bottom Line: Focus on good CPR and proper BLS/ALS care.   Give epi for cardiac arrest.  Give Naloxone for respiratory arrest. 

***

Considerations:

This is a theoretical scenario, which I will discuss further in a future post on the topic of rigid chest syndrome and illicit fentanyl use.  If the patient in recent cardiac arrest proves difficult or impossible to ventilate  consider Naloxone.  This is on the theory that the the patient is suffering from rigid chest syndrome caused by some combination of a large dose, a fast push or just simply the properties of fentanyl.  Rigid chest syndrome, which is rare in the clinical setting, can cause the glottis to close, making ventilation impossible.  It is uncertain how long after the patient's heart stops beating the rigidity lasts or whether the patient simply becomes flaccid as they do after a hypoxic seizure.  Rigid chest syndrome should respond to Naloxone.

As always, please follow your local medical control treatment protocols and guidelines.

***

For more on the controversies surrounding the use of naloxone in cardiac arrest, read the multiple and excellent columns by Rogue Medic

The Myth That Narcan Reverses Cardiac Arrest

Naloxone and Cardiac Arrest