Tuesday, October 31, 2017

Hope

 

The call is for an overdose in the stairwell of the apartment building. Fire has arrived just before us – they have propped the front door open. I enter with my house bag over my shoulder and carrying the cardiac monitor in my right hand. There is no one in the dim lobby to direct me. I go through the door to the ground floor hallway. I see a stairwell to the far right and one to the far left. I take the one to the right. I don’t hear anyone in the stairwell, so I take the stairs two at a time (I am six eight so this is not too hard for me). I get to the top without encountering fire or an overdose. I come out on the fourth floor, and the go down the hall all the way to the far stairwell, and head down taking them only one at a time (I am 59 and my balance is not the best). I am back down on the ground floor with no patient. I have at least caught up with two firefighters who are trying to radio their fellow crew members to see if they have found anything. I head back up the stairs, stopping on each floor to look and listen. Finally, on my way back down, a door opens on the second floor and a man waves us in. 

The girl is sprawled on the couch. A firefighter is there with her, bagging her. He has given her 4 mg IN, but she is still not breathing on her own other than an occasional gasp. I put her on the ETCO2 and her number is 60, but the number quickly drops to 40 before I can get my Narcan out, and she is now breathing better. A little sternal rub and she opens her eyes.

“You overdosed,” the firefighter says.

She shakes her head and slowly sits. “I’m so embarrassed,” she says.

She is in her early thirties and looks striking like the actress Scarlett Johansson, except she has hard miles on her face and she is a heroin addict. The firefighter says she overdosed yesterday too. They found her in a car on Williams Street.

“I am so sorry,” she says. “I was clean for four months and I relapsed yesterday. And here I am again. I’m sorry.”

I notice her boyfriend is also in the room. He is a tall burly man with a beard. He is clearly high on heroin himself. His pupils are pinpoint and he speaks in an odd whispery voice. He is a little unsteady in the knees. He says they are from out of town, but know the person whose apartment we are in. The boyfriend shot her up in the stairwell before they went to the man’s apartment, not wanting to involve him in their addiction. When she stopped breathing he called 911 on his cell phone and then after getting the man to help, they carried her into the man’s apartment. The boyfriend says he bought the drugs in Hartford on Park Street. He shows me the bags. They are blank.

The girl still has her head in her hands. “I have to be at work at 10,” she says.

A police officer is there and wants to know where the syringe is. The boyfriend says he left it in the stairwell. “Where a kid can find it!” the officer says.

“I’m sorry, I panicked. I needed to get her help,” he says.

They go off to find the syringe. The girl stands slowly and walks out of the apartment with us, over to the small elevator which we take slowly to the ground floor where my partner has the stretcher set up.

I am thinking she looks familiar to me. I remember now where I saw her. She overdosed in the Subway bathroom last summer on the “Fastrack” brand. She was on the ground, blue and agonal. We brought her around with Narcan. I remember her being very apologetic then. We had a very good conversation about the brands. She wanted to know which ones were most dangerous (the ones with Fentanyl) so she could avoid them. “Stay away from Fastrack,” I’d told her.

“Lesson learned,” she’d said.

On the way to the hospital, I ask her how she first got involved with opioids. I am expecting her to tell me as so many do that she got into a car accident or was injured somehow and her doctor gave her a six-month prescription to oxycodone and she got hooked. From there it was easy to make the switch over to heroin, which is cheaper and more readily available. Instead she says. “I don’t remember. I’m an addict. I’ve always been an addict. It’s who I am.”

We drive along in silence.

“If I don’t get to work by ten, I am going to lose my job,” she says. She is a waitress at an all-night diner.

It’s six-thirty now. A couple hours in the ED, and she may get out in time.

“Don’t give up hope,” I say.

***

The call is for an overdose in the bathroom of a fast food restaurant. We arrive to a find a stocky bearded man in his thirties in the bathroom, sitting on the toilet, his pants around his legs, he is cyanotic, his head against the wall, mouth open, pinpoint pupils, not breathing but he is warm and has a pounding carotid pulse. He does not respond to stimulation. While my partner gets out the ambu-bag, I take out the Narcan, and instead of attaching an atomizer to the end, I put on a needle and inject 1.2 mg into his bare thigh. I just want to get him back breathing rather than waiting all the extra time, trying to get a decent seal around his beard. Plus, I don’t know how long he has been hypoxic. I am getting ready to put an oral airway in his mouth. He wakes suddenly and looks up with a start to see me standing over him holding the oral airway, my partner with the ambu-bag, and three firefighters.

“You’re in a public bathroom,” I say. “You overdosed. We just gave you Narcan.”

“Overdosed? What are you talking about? I didn’t overdose.”

“You weren’t breathing. We gave you Narcan.”

“I don’t know what you are talking about.”

“You likely did heroin.”

“Heroin, I don’t know what you are talking about.” He looks away from me quickly, his eyes darting about the room, eyelids blinking.

“Stand up and put your pants on.”

“What are you talking about?”

“You are sitting on a toilet.  Your pants are around your ankles. Pull your pants up. The bathroom door’s wide open.  There are people eating.”

He stands with our help, and we get his pants up. “I don’t know why you are all here?”

“Look,you are not in trouble. You weren’t breathing, we gave you a drug that counteracts opioids and now you are talking to us.”

“I don’t do drugs.” He glances furtively toward the open bathroom door. I think if there were not so many people in the bathroom, he might bolt.

“Okay, whatever," I say.  "We are taking you to the hospital.”

“I don’t think that’s necessary.” I think he is hoping we will all go away and he can just leave and forget this episode ever happened.

“The drug we gave you doesn’t last as long as whatever you took.  You could stop breathing again.”

He looks at me a moment, considering.

“We can take you to either Hartford or Saint Fran.”

“Saint Francis,” he said. “But I really don’t understand this.”

 

We get him on the stretcher. On the way out of the restaurant he clicks his car keys. The lights flash in the black Honda Accord parked at the curb.  We get him in the back of the ambulance and get on our way to the hospital. His forehead is beaded with sweat.   hand him an emesis basin when he says he is nauseous. 

“Listen,” I say. "You know where to get Narcan?”

He looks at me, waiting.

“Go to a pharmacy. Are you on Medicaid or do you have insurance?”

He nods.

“Go to a pharmacy. They will write you a prescription. If you are on Medicaid, it’s free. You live with your girlfriend or your family, and they know you have a problem, then need to know where to get it if they find you overdosed.”

He is paying attention.

“You have to be careful with the fentanyl.  You get a bag that has more than it should, next thing you know you wake up on the toilet looking at me.”

His eyes are wet. I think I am getting through.

“Never do it alone, and you make certain you have Narcan. You buy from a new source, you just do a tester shot, you can always do more. If you have to do it by yourself, do it where someone can find you. If you are in a public bathroom, set a timer that will buzz like crazy if you don’t turn it off. Or I know some people will stuff up the sink, and start the water going so it they OD, the overflowing water will alert someone. I’m not telling you to do that, I’m using it as an illustration. If not, then you better hope that like today there was a dude standing outside the bathroom door, needing to take a piss or drop a log, and said something to the manager about the door being locked and no one answering when he knocked.  No dude needing to take a piss, and you wind up dead. When we finally get to you, the Narcan won’t work. You hear what I’m saying?”

“Yeah,” he says.

“Good.” I hand him a card with the state opioid hotline number on it. “Call this number when you’re ready for help."

He takes the card and put it in his shirt pocket.

“It’s a long road, but you can beat this,” I say.

“I think I’m going to throw up,” he says.

“That’s what the emesis bag is for.”

He retches. 

At the hospital, we put him on a bed in the hallway. After I give the report to the nurse, she goes over to him. “I don’t even know why I am here?” he says. “I don’t do drugs.”

Two hours later, we drive past the fast food restaurant. The black Honda Accord is no longer out front.

Somewhere on Park Street a car window rolls down.

Friday, October 27, 2017

Controversies and Carfentanil

 

Great article in the November 2017 edition of the  American Journal of Emergency Medicine about the  controversies surrounding the dangers of carfentanil, fentanyl and other fentanyl analogues.  The physician authors, John B. Cole and Lewis S. Nelson, take the Drug Enforcement Agency (DEA) and the media to task for sensationalizing the dangers to responders of these synthetic opioids.

They write that the DEA guidance that mucosal or dermal absorption of fentanyl can rapidly kill and the DEA video of two officers suffering symptoms following accidental exposure should, based on "real world and foundational" evidence, "be treated with healthy skepticism."  They note that the officers' symptoms are "inconsistent with opioid poisoning."  They also note that "it is unquestionable that both drug user and sellers contact the product on a regular basis without apparent harm."

Last month in Connecticut, the acting head of the DEA, Chuck Rosenberg, speaking at a Yale Law School Opioid Conference, continued to repeat the DEA's party line.

“It will kill you,” Rosenberg said. And for those with no tolerance, Rosenberg warned: “It can kill you to the touch.”

Hartford Courant story

The DEA and the media continue to spread this false information, and the result can lead to responders failing to act quickly to save people whose lives are endangered.  The DEA briefing guide on fentanyl still urges responders to back off when encountering cyanotic patients.

 "Personnel should look for any cyanosis (turning blue or bluish color) of victims, including the skin or lips, as this could be a sign of fentanyl overdose caused by respiratory arrest. Further, before proceeding, personnel should examine the scene for any loose powders (no matter how small), as well as nasal spray bottles, as these could be signs of fentanyl use.  Opened mail and shipping materials located at the scene of an overdose with a return address from China could also indicate the presence of fentanyl, as China‐based organizations may utilize conventional and/or commercial means to ship fentanyl and fentanyl‐related substances to the United States."

"Before proceeding" to take care of a cyanotic patient on the verge of anoxia or death, the DEA wants you to look for packages from China.

On July 26, the Los Angeles Times, in a story about a drug overdose scene, 1 dead, 2 others hospitalized after authorities find white powder in Santa Ana apartment, reported: “A small dose of the odorless white power can be fatal."   The paper records an official describing the police response to an overdose call: “Officers have been trained to “back off” when they come across white powder and an unconscious victim at the scene of a call, he said.”

Fentanyl: A Briefing Guide for First Responders

The Drug Enforcement Agency needs to issue a correction.

American Journal of Emergency Medicine  article contains a graph listing five safety concerns and the "rational for skepticism."  Here are the five concerns:

Inhalational route of exposure

Dermal absorption

Opioid poisoning from scenes with powdered opioids

Canines poisoned and revived with naloxone may be a harbinger of human poisoning

Description of "poisoning" from drug powder in the air from brushing powder off clothes. 

The answers to the concerns are convincing.  For instance, they note that "dermal absorption requires solubized drug and permeation enhancers to reach concerning blood concentrations and rates of absorption are low."  When talking about the comparison of the dangers to dogs and humans, they make the distinction, "Unlike humans, dogs place noses extremely close to objects they smell; dogs also lick their noses after smelling."

The authors also have some fascinating things to say about carfentanil.

People die from opioids, they write, due to induced apnea.  Carfentanil actually produces less apnea when given at its proper dose than many other synthetic opioids.  The deaths from carfentanil come from uncontrolled dosing.  When drug dealers learn to dose it properly, carfentanil deaths should decline.  A harm reduction worker told me that drug dealers may currently avoid carfentanil because there isn’t yet a good way for them to properly dose it.  As heartless as drug dealers may be, it is bad for business to kill twenty customers in a few hours if the batch is not mixed right.  The risk of using carfentanil (multiple murder indictments) currently outweighs the benefit to many drug dealers.

Carfentanil was the drug used in the Moscow theater hostage catastrophe in 2002.  The authors note that while the Russians weaponized the carfentanil for maximum absorption, only 15% of the hostages succumbed.  At a talk I recently attended on EMS provider safety, the speaker, a toxicologist, showed pictures of the event, including ungloved and unmasked responders removing people from the scene.  None of the responders, the speaker pointed out,  reported any ill effects.

The authors also tackle the question of how much naloxone is needed to counteract a carfentanil overdose and they report that animal data suggests that carfentanil should respond to naloxone at traditional dosing levels.  They emphasize the goal of naloxone is not to wake the person up, but simply to restore effective respirations.  I wonder if all the reports of massive doses needed to revive “carfentanil” overdoses are not a combination of the increasing prevalence of IN naloxone with a slower onset, impatience on the part of responders,* multiple response agencies carrying naloxone now all arriving within minutes of each other and each higher level arriving delivering the drug, responders using the end point of consciousness as their target not restoration of respirations, and the self fulfilling idea that carfentanil overdoses require massive amounts of naloxone, so responders are quicker to deliver more doses.

The authors conclude by suggesting instead of thinking of heroin, fentanyl or carfentanil overdoses in specific, we should be categorizing them all as opioid overdoses and treating them in the same way.  For provider safety, they say standard PPE is reasonable.

Controversies and carfentanil: We have much to learn about the present state of opioid poisoning

* Naloxone can take up to 15 minutes to reach full absorption through the atomizer method according to intranasal.net.

Thursday, October 26, 2017

Falsehood Flies

 

“Falsehood flies, and truth comes limping after it, so that when men come to be undeceived, it is too late; the jest is over, and the tale hath had its effect.” - Jonathan Swift

This quote came to me from a respected toxicologist after reading some news accounts of public safety response to possible fentanyl overdose scenes.

The falsehood that just touching fentanyl can kill you has persisted despite the recently published position paper by The American College of Medical Toxicology and the American Academy of Clinical Toxicology that it is not so.

ACMT and AACT Position Statement: Preventing Occupational Fentanyl and Fentanyl Analog Exposure to Emergency Responders

On July 26, the Los Angeles Times, in a story about a drug overdose scene, 1 dead, 2 others hospitalized after authorities find white powder in Santa Ana apartment, reported: “A small dose of the odorless white power can be fatal.  In some cases, just touching the powder could trigger an overdose like it did this year in Ohio.”  They go on and talk about the widely reported case of the officer in Ohio, who “accidentally overdosed on fentanyl when he brushed off a powdery substance from his shirt.”

That case triggered an article in Slate magazine, The Viral Story About the Cop Who Overdosed by Touching Fentanyl Is Nonsense.

My read on that story (without any knowledge except the news reports) is that if the officer truly overdosed (suffered respiratory depression) it was from inhalation, not touching.

The LA Times story describes the police response to an overdose call: “Officers have been trained to “back off” when they come across white powder and an unconscious victim at the scene of a call, he said.”

It is unclear from the article whether treatment was delayed to the three overdose victims, one of whom died. Hopefully, medics (with proper PPE) were allowed to go right in to treat the patients.

The danger to repeated bad information is critical care will be delayed due to unwarranted fear.  The spector of pile of fentanyl powder suddenly morphing into a devilish cloud that strikes down a brigade of responders is science fiction.  Leave the powder be, wear PPE and take care of the human being in respiratory depression.

“A woman and three children were also found in the 800-square-foot apartment and removed, Bertagna said. They, along with the officers and paramedics, all underwent decontamination, essentially an intense shower.”

Is this going to be the new standard after every overdose call?

The next day, the Wall Street Journal had a front page article: Fentanyl Isn’t Just Deadly for Drug Users: Police Are Getting Sickened.

The Journal article was fascinating in its detail of how the fear of the drug has transformed the way everyone from local cops to medical examiners to prosecutors handle their business.  The Journal, which made no mention of the toxicology paper, cited not only the case of Ohio officer, but the Maryland officer who had Naloxone sprayed into his nose while he was still conscious and talking.  They never bothered to attach the atomizer because they were so panicked that there wasn't time to save him.  Needless to say, he did not meet guidelines for the administration of Naloxone.

Md. Officer Recounts Exposure to Heroin, Fentanyl on Overdose Call

While it is hard to comment on actual calls, when all we have our newspaper accounts, which can be inaccurate, all we can do is comment on the account.

There is clearly an atmosphere of fear in these articles and accounts that feeds into hysteria.

The LA Times article cites the officer reciting the mantra from the DEA’s document that when you see powder and a cyanotic patient, you step back.  The DEA, in their Fentanyl: A Briefing Guide for First Responders, writes:

Personnel should look for any cyanosis (turning blue or bluish color) of victims, including the skin or lips, as this could be a sign of fentanyl overdose caused by respiratory arrest. Further, before proceeding, personnel should examine the scene for any loose powders (no matter how small), as well as nasal spray bottles, as these could be signs of fentanyl use. Opened mail and shipping materials located at the scene of an overdose with a return address from China could also indicate the presence of fentanyl, as China‐based organizations may utilize conventional and/or commercial means to ship fentanyl and fentanyl‐related substances to the United States.

The Journal article at least cites an officer who while recognizing this, says, “If someone is there not breathing no police officer I know is going to spend five minutes putting on personal protective equipment.”

My fear is that some responders will delay helping critical patients to put on excess PPE (Think ET) or call in Haz Mat teams, when all they need is gloves, and an N-95 mask, which takes only moments to put on.  Delay in treatment caused by unnecessary fear will cost human lives.

On July 30, an article in the Eagle-Tribune, Mass. Fire Chief Seeks Improved Protocols for Opioid Overdoses, describes a town spending $75,000 on a hazmat response to a scene where three people overdosed.  The article includes the line: “The fear on Garden Street that morning was the men had overdosed on either fentanyl or carfentanil, an even stronger man-made opioid that can be toxic to someone merely in its presence.”

There is no scientific evidence that fentanyl or carfentanil are toxic to anyone who is merely in the same room as the drug.  The danger is inhalation or injection.  If you wear proper PPE, there is little risk in treating your patients.

To his great credit, the local Fire Chief asks the state for improved guidance on how to handle these situations.

"I definitely think this needs to be reviewed... It's always safer to have an abundance of caution than to ignore it. But we need to work on the future of how we are going to handle this," Moriarty said.

He explained that for years firefighters have used universal precautions—gloves, masks and eye goggles—when they respond to medical aid calls, including reports of overdoses.

Now, when are those universal precautions sufficient? he asked.

The American College of Medical Toxicology and the American Academy of Clinical Toxicology's joint statement on "Preventing Occupational Fentanyl and Fentanyl Analog Exposure to First Responders" states “the risk of clinically significant exposure to emergency responders is extremely low.”

What is the logical extension of the DEA's reasoning?  There are millions of addicts in the country who inhale and inject powdered heroin and/or fentanyl multiple times a day.    Are they all walking hazmat scenes? Could they have grains of powder in their clothing? Does this mean that if you have a history of heroin use you, on entry into an ambulance or hospital, will be treated like a potential Ebola patient, requiring isolation rooms, decontamination and health personnel donning and doffing high level PPE?  All because of the misguided belief that touching the powder can kill.

It is time for the national emergency physician organizations and state EMS offices to speak out on the debate and hopefully end the hysteria before it truly gets out of control.

Stay safe.  Wear your PPE.  And take care of your patients.

 

Saturday, October 07, 2017

Endocarditis

 The patient is "a skin popper."  She injects heroin into her skin rather than snorting it or injecting it directly into her veins.  Her arms are covered with sores in various stages of ulceration from old scars to open weeping sores. 

example of skin popper
The ambulance crew is there not for an overdose, but for chest pain and confusion.  The medic puts  electrodes on the woman's chest and does a rapid 12-lead ECG.  The ECG shows huge anterior ST-segment elevations.    The 12-lead is transmitted and then a STEMI ALERT is made to the receiving hospital.  The cath team meets the patient at the ED door, but the doctor is concerned that the patient is having difficulty comprehending the consent instructions and is unable to write her name.  She is sent to the CT scan before being rushed up to the cath lab.  A Stroke Alert is called and as soon as the cath lab team has pulled several emboli out of her occluded left anterior descending artery, the neurology team takes over.  The CT scan revealed multiple septic emboli in the brain as well.  Septic embolic are small emboli filled with pus and bacteria that likely broke away from the vegetation in the patient’s heart values.  The patient suffers, like many drug users who use dirty needles, from endocarditis.  If her heart were a carburetor, the mechanics would throw it out rather than attempt repair it it is so gunked up.
 
 
[caption id="attachment_13629" align="alignnone" width="300"] http://circ.ahajournals.org/content/107/20/e185/F2[/caption]

Bacterial Endocarditis

Endocarditis is epidemic in the United States today.  It’s rise mirrors the rise of opioid deaths. While this patient’s demise will not be counted in the overdose death numbers, she is nonetheless a casualty of the opioid epidemic that is destroying people, families and communities across the country.  The woman is very sick.  Too much damage has been done to her heart and brain.  After a discussion with her loved ones, she receives a final opioid -- morphine, then she is extubated, and with family at her side, she passes on. 

 
 
***
 
Endocarditis can come from using dirty needles.  Tell your patients where they can get clean needles.  In Hartford, they can go to the needle exchange van.  Here is the schedule:
 
Monday - Friday
  • 7:15 AM - 9:45 AM (Park & Hungerford St.)
  • 11:00 AM - 12:45 PM (Albany Ave. & Bedford St. by CHS)
  • 2:00 PM - 2:50 PM (Park & Hungerford St.)
They can also contact the Greater Hartford Harm Reduction Coalition at  860-250-4146.
 
 In Connecticut, users can purchase 10 syringes at their local pharmacy for about $4.  They do not need a prescription.

Thursday, October 05, 2017

Non-Opioid Pain Management

 


The state of Massachusetts just passed an emergency protocol change requiring all paramedic ambulances to carry non opioid pain management alternatives, including Ibuprofen PO, Acetaminophen PO and Ketorolac IV or IM.  Acetaminophen IV is optional.  The changes are to take place January 1, 2018.

Massachusetts Pain Management Protocol

Emergency Non-Opioid Pain Treatment Options Update

Here is the dosing regime:

Adult

Acetaminophen 1000 mg IV or PO

Ibuprofen 600 mg PO

Ketorolac  15 mg IV or 30 mg IM

Pediatric

Acetaminophen 15 mg/kg IV or PO to max 1000 mg.

Ibuprofen 10 mg/kg PO to max 600 mg.

Ketorolac 0.5 mg/kg IV or IM to max 15 mg.

The Massachusetts protocol includes the following note:

All pain medications have contraindications-do not administer medications in

such circumstances. These contraindications include but are not limited to:

Ketorolac and ibuprofen are contraindicated in head injury, chest pain, abdominal pain,

or in any patient with potential for bleeding, ulcer, or renal injury; likely to need surgery

Acetaminophen is contraindicated in patients with liver failure. Ketorolac and ibuprofen

are contraindicated in pregnancy.

Many states, including Massachusetts and Connecticut, have been passing laws allowing patients to fill out non-opioid directive forms.  This will allow patients who want to avoid opioids a pain management alternative beyond ice and splinting.  I have had many patients decline opioids, ranging from patients in recovery to  patient to others fearful that “Fentanyl” will send them down the road to addiction and death.  While those fears are largely unrealistic in the context of fentanyl being used for an acute painful injury, avoiding opioids if there is another alternative is probably not a bad idea.

I was not even aware that Acetaminophen  could be given by the IV route or that it was considered as effective as morphine, but a recent randomized controlled study published in Trauma Monthly showed it was safe and efficacious and even outperformed morphine in the trial.

Efficacy of Intravenous Paracetamol Versus Intravenous Morphine in Acute Limb Trauma.

One drawback to IV Acetaminophen is its price -- $36 for a one dose 1 gram vial, compared to $2.40 a dose for fentanyl or morphine.  As it so often seems, the price of a suddenly popular drug seem to suddenly skyrocket.

When IV Acetaminophen Prices Suddenly Skyrocketed

IV APAP Works, So Why Don’t More EPs Use It?

Our Regional Medical Advisory Committee will be considering a similar protocol when we meet next week.  In our area, the cost of IV acetaminophen might be mitigated by the savings of not having to take an ambulance off-line for controlled substances exchanges at a hospital pharmacy every time they use Fentanyl or Morphine.